Hot Selling and High Quality Cesium Carbonate CAS 534-17-8 with Good Price

PrMany properties of cesium carbonate in organic synthesis are derived from the soft Lewis acidity of cesium ion, which makes it soluble in organic solvents such as alcohols, DMF and ether. The better solubility in organic solvents enables cesium carbonate to participate in chemical reactions catalyzed by palladium reagents as an effective inorganic base, such as Heck, Suzuki and Sonogashira reactions. For example, Suzuki cross coupling reaction with cesium carbonate was able to obtain 86% yield, while the same reaction with sodium carbonate or triethylamine was only 29% and 50%. Similarly, in the Heck reaction of methacrylate and chlorobenzene, cesium carbonate compared with other inorganic bases, such as potassium carbonate, sodium acetate, triethylamine, potassium phosphate, showed a very obvious advantage. Cesium carbonate also has important applications in the o-alkylation of phenol compounds. It is speculated that the phenol O-alkylation reaction in cesium carbonate non-aqueous solvent is likely to experience the phenoxyethylene anion, so the alkylation reaction can also take place for the secondary halogenates with high activity and easy elimination reaction. Cesium carbonate also has important applications in the synthesis of natural products. For example, in the synthesis of Lipogrammistin-a compound in A key step closed-loop reaction, cesium carbonate as an inorganic base can be used to obtain closed-loop products with high yield. In addition, cesium carbonate has important applications in solid supported organic reactions due to its good solubility in organic solvents. Carboxylate or carbamate compounds can be synthesized at a high yield by inducing a three-component reaction of aniline with a solid supported halogen in a carbon dioxide atmosphere. Under microwave irradiation, cesium carbonate can also be used as a base to realize esterification reaction between benzoic acid and solid supported halogenates.